Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Identifieur interne : 000247 ( an2020/Analysis ); précédent : 000246; suivant : 000248Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza‐minika A. Chevalier (Ebenaceae)
Auteurs : Jean Gustave Tangmouo [Cameroun, Suisse] ; Raimana Ho [Suisse] ; An Matheeussen [Belgique] ; Alain Meli Lannang [Cameroun] ; Justin Komguem [Cameroun] ; Bernadette Biloa Messi [Cameroun, Suisse] ; Louis Maes [Belgique] ; Kurt Hostettmann [Suisse]Source :
- Phytotherapy Research [ 0951-418X ] ; 2010-11.
Abstract
The methanol extract from the stem bark of Diospyros sanza‐minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC‐5 cells. 4‐O‐(3′‐methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4‐O‐galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11‐O‐p‐hydroxy‐benzoyl‐norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.3192
Affiliations:
- Belgique, Cameroun, Suisse
- Canton de Genève, Province d'Anvers, Région flamande
- Anvers, Genève
- Université d'Anvers, Université de Genève
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Norbergenin and 4‐O‐syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza‐minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Cameroun</li><li>Suisse</li></country><region><li>Canton de Genève</li><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li><li>Genève</li></settlement><orgName><li>Université d'Anvers</li><li>Université de Genève</li></orgName></list><tree><country name="Cameroun"><noRegion><name sortKey="Tangmouo, Jean Gustave" sort="Tangmouo, Jean Gustave" uniqKey="Tangmouo J" first="Jean Gustave" last="Tangmouo">Jean Gustave Tangmouo</name></noRegion><name sortKey="Komguem, Justin" sort="Komguem, Justin" uniqKey="Komguem J" first="Justin" last="Komguem">Justin Komguem</name><name sortKey="Lannang, Alain Meli" sort="Lannang, Alain Meli" uniqKey="Lannang A" first="Alain Meli" last="Lannang">Alain Meli Lannang</name><name sortKey="Messi, Bernadette Biloa" sort="Messi, Bernadette Biloa" uniqKey="Messi B" first="Bernadette Biloa" last="Messi">Bernadette Biloa Messi</name></country><country name="Suisse"><region name="Canton de Genève"><name sortKey="Tangmouo, Jean Gustave" sort="Tangmouo, Jean Gustave" uniqKey="Tangmouo J" first="Jean Gustave" last="Tangmouo">Jean Gustave Tangmouo</name></region><name sortKey="Ho, Raimana" sort="Ho, Raimana" uniqKey="Ho R" first="Raimana" last="Ho">Raimana Ho</name><name sortKey="Hostettmann, Kurt" sort="Hostettmann, Kurt" uniqKey="Hostettmann K" first="Kurt" last="Hostettmann">Kurt Hostettmann</name><name sortKey="Hostettmann, Kurt" sort="Hostettmann, Kurt" uniqKey="Hostettmann K" first="Kurt" last="Hostettmann">Kurt Hostettmann</name><name sortKey="Hostettmann, Kurt" sort="Hostettmann, Kurt" uniqKey="Hostettmann K" first="Kurt" last="Hostettmann">Kurt Hostettmann</name><name sortKey="Messi, Bernadette Biloa" sort="Messi, Bernadette Biloa" uniqKey="Messi B" first="Bernadette Biloa" last="Messi">Bernadette Biloa Messi</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Matheeussen, An" sort="Matheeussen, An" uniqKey="Matheeussen A" first="An" last="Matheeussen">An Matheeussen</name></region><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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